Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinomas in a transgenic mouse model

A transgenic mouse model was used to evaluate the effect of endostatin trea tment on spontaneous turnorigenesis, In this model system, female mice deve lop multiple mammary adenocarcinomas and male mice develop prostate cancer. Female mice treated with mouse endostatin during a 12-15-week period showe d delayed tumor development by 4-6 weeks and significantly decreased tumor burden. Furthermore, endostatin treatment reduced the number of malignant l esions per mouse. In a separate set of experiments. male mice treated with endostatin showed a survival advantage, and their life spans were prolonged by 10.5 weeks over control animals. These data demonstrate that mouse endo statin is effective in delaying spontaneous tumor development and growth.