Synthesis and superoxide dismutase activity studies of beta-cyclodextrin derivatives containing 1,2-benzisoselenazol-3 (2H)-one

Two novel beta-cyclodextrin derivatives containing 1,2-benzisoselenazol-3 ( 2H)-one have been synthesized by a convenient method in 60% and 55% yields, respectively, and characterized by elemental analysis, IR and H-1 NMR, The superoxide dismutase (SOD) activity of these modified beta-cyclodextrins h as been determined by the method of autooxidation of pyrogallol at 298. 15 K in buffer solution(pH = 8.20). The results obtained indicate that these c yclodextrin derivatives possesses relatively high SOD activity up to 179 si milar to 330 U/mg.