Bone marrow and peripheral blood hematopoietic stem cell transplantation: Focus on autografting

This review focuses on certain of the principles involved in high-dose chem otherapy and radiation therapy along with autologous hematopoietic stem cel l transplantation for the treatment of certain malignancies. In addition, t he evidence, wherever possible based on randomized data, for the applicatio n of this approach in certain malignancies is reviewed. The malignancies hi ghlighted include acute myeloid leukemia, acute lymphoblastic leukemia, non -Hodgkin lymphoma, Hodgkin disease, and breast cancer. (C) 2000 American As sociation for Clinical Chemistry.