HIGH-DENSITY-LIPOPROTEIN INHIBITS PLATELET 12-LIPOXYGENASE ACTIVITY

Authors
FUJIMOTO Y TSUNOMORI M MUTA E YAMAMOTO T NISHIDA H SAKUMA S FUJITA T
Citation
Y. Fujimoto et al., HIGH-DENSITY-LIPOPROTEIN INHIBITS PLATELET 12-LIPOXYGENASE ACTIVITY, Research communications in molecular pathology and pharmacology, 85(3), 1994, pp. 355-358
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
85
Issue
3
Year of publication
1994
Pages
355 - 358
Database
ISI
SICI code
1078-0297(1994)85:3<355:HIP1A>2.0.ZU;2-A
Abstract
The effects of high density lipoprotein (HDL) and low density lipoprot ein (LDL) on the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic ac id (12-HETE), thromboxane (TX) B-2 and 12-hydroxy-5,8,10-heptadecatrie noic acid (HHT) in washed rabbit platelets were examined. HDL had a po werful inhibitory effect on 12-HETE formation, while it produced only a small increase in TXB(2) and HHT formation. LDL did not affect the f ormation of 12-HETE, TXB(2) and HHT. These results suggest that HDL is a selective inhibitor of platelet 12-lipoxygenase and may play a prot ective role in atherogenesis by preventing the generation of 12-HETE.