Cloning and characterisation of ITGAV, the genomic sequence for human celladhesion protein (vitronectin) receptor alpha subunit, CD51

The integrin family of receptors serves as major receptors for extracellula r matrix-mediated cell adhesion and migration, cytoskeletal organisation, c ell proliferation, survival, and differentiation. The alpha-V integrins con sist of a subset which share a common alpha-V subunit combined with one of five beta subunits (beta-1, 3, 5, 6, or 8). The alpha-V integrins have been implicated in a number of developmental processes, including vasculogenesi s and angiogenesis, and are therapeutic targets for inhibition of angiogene sis and osteoporosis. The human cDNA for alpha-V integrin (ITGAV) consists of a 5,717-bp transcript with a coding sequence (CDS) of 3,146 bp encoding a 150-kDa mature peptide. Here we describe the gene structure of ITGAV. Cop yright (C) 2000 S. Karger AG, Basel.