The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4

TBC1D1 is the founding member of a family of related proteins with homology to (t) under bar re-2/UPS6, (B) under bar UB2, and (c) under bar dc16 and containing the tbc box motif of 180-220 amino acids. This protein family is thought to have a role in differentiation and in regulating cell growth. W e set out to map the TBC1D1 gene in mouse and human. Segregation analysis o f a TBC1D1 RFLP in two independent mouse RI (recombinant inbred) lines reve als that mouse Tbc1d1 is closely linked to Pgm1 on chromosome 5. The human TBC1D1 gene was assigned to human chromosome 4p15.1 --> 4q21 using Southern blot analyses of genomic DNAs from rodent-human somatic cell lines. A huma n-specific genomic fragment was observed in the somatic cell lines containi ng human chromosome 4 or the 4p15.1 --> 4q21 region of the chromosome. TBC1 D1 maps to the region containing the ortholog of mouse Pgr,ll adding anothe r locus to this long region of conserved synteny between mouse and man. Cop yright (C) 2000 S. Karger AG, Basel.