Inhibition of matrix metalloproteinase-9 (MMP-9) activity by cleistanthin A, a diphyllin glycoside from Cleistanthus collinus

Authors
Meenakshi, J Shanmugam, G
Citation
J. Meenakshi et G. Shanmugam, Inhibition of matrix metalloproteinase-9 (MMP-9) activity by cleistanthin A, a diphyllin glycoside from Cleistanthus collinus, DRUG DEV R, 50(2), 2000, pp. 193-194
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT RESEARCH
ISSN journal
02724391 → ACNP
Volume
50
Issue
2
Year of publication
2000
Pages
193 - 194
Database
ISI
SICI code
0272-4391(200006)50:2<193:IOMM(A>2.0.ZU;2-O
Abstract
Matrix metalloproteinases (MMPs) are responsible for the remodeling of the extracellular matrix throughout the body. Inhibitors of these enzymes have been suggested as potential therapeutic agents for use in treatment of canc er. Our observations showed that cleistanthin A, a diphyllin glycoside from the leaves of the plant Cleistanthus collinus inhibited MMP-9, a 92 kDa ma trix metalloproteinase. Further evaluation of this compound might reveal ma ny such novel properties that might help in the evolution of this compound as an anticancer drug. (C) 2000 Wiley-Liss, Inc.