Hormone replacement therapy and the risk of myocardial infarction in womenwith coronary risk factors

To assess the risk of myocardial infarction in users of postmenopausal horm one replacement therapy who are at high risk of coronary disease because of hypertension, diabetes mellitus, or smoking, we used data from a previousl y published case control study of women 45-74 years. After adjustment for a ge, ethnicity, and education, the odds ratio for myocardial infarction in c urrent users of hormone replacement therapy was 0.9 (95% confidence interva l (CI) = 0.5-1.6) in women with no major coronary risk factors, 0.8 (95% CI = 0.5-1.8) in women with one risk factor, and 1.1 (95% CI = 0.5-2.2) in wo men with two risk factors.