Synthesis and antineoplastic activity of cyclolignan aldehydes

Authors
Gordaliza, M Castro, A del Corral, JM Lopez-Vazquez, L Garcia, PA Garcia-Gravalos, D San Feliciano, A
Citation
M. Gordaliza et al., Synthesis and antineoplastic activity of cyclolignan aldehydes, EUR J MED C, 35(7-8), 2000, pp. 691-698
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234 → ACNP
Volume
35
Issue
7-8
Year of publication
2000
Pages
691 - 698
Database
ISI
SICI code
0223-5234(200007/08)35:7-8<691:SAAAOC>2.0.ZU;2-Z
Abstract
Several aldehydes related to methyl 9-deoxy-9-oxo-alpha-apopicropodophyllat e, a selective antitumour agent against the HT-29 colon carcinoma, have bee n prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). All of them lacked the lactone ring but maintained their cytotoxicity at, or under, the mu M level. (C) 2 000 Editions scientifiques et medicales Elsevier SAS.