Evidence for a protein related immunologically to the jaagsiekte sheep retrovirus in some human lung tumours

Citation
M. De Las Heras et al., Evidence for a protein related immunologically to the jaagsiekte sheep retrovirus in some human lung tumours, EUR RESP J, 16(2), 2000, pp. 330-332
Citations number
17
Categorie Soggetti
Cardiovascular & Respiratory Systems","da verificare
Journal title
EUROPEAN RESPIRATORY JOURNAL
ISSN journal
09031936 → ACNP
Volume
16
Issue
2
Year of publication
2000
Pages
330 - 332
Database
ISI
SICI code
0903-1936(200008)16:2<330:EFAPRI>2.0.ZU;2-O
Abstract
Human bronchioloalveolar carcinoma (BAC) is a lung cancer morphologically s imilar to an endemic contagious lung neoplasm of sheep called sheep pulmona ry adenomatosis (SPA) or jaagsiekte, SPA is caused by an exogenous type B/D retro vi;us (jaagsiekte sheep retrovirus (JSRV)), which prompted the prese nt study to obtain evidence of a retrovirus in BAG. A panel of 249 human lung tumours, 21 nontumour lung lesions, four normal l ung tissues, 23 adenocarcinomas from other organs and a cell line expressin g a human endogenous retrovirus protein was examined immunohistochemically using a rabbit antiserum directed against the JSRV capsid protein, Specific staining was detected only in the cytoplasm of recognizably neopla stic cells in the pulmonary alveoli of 39 of 129 (30%) BACs, 17 of 65 (26%) lung adenocarcinomas and two of seven large cell carcinomas. The remaining samples were negative. These results support the hypothesis that some human pulmonary tumours may be associated with a jaagsiekte sheep retrovirus-related retrovirus, warran ting further studies.