THE INFLUENCE OF COFFEE WITH MILK AND TEA WITH MILK ON THE BIOAVAILABILITY OF TETRACYCLINE

Authors
JUNG H PEREGRINA AA RODRIGUEZ JM MORENOESPARZA R
Citation
H. Jung et al., THE INFLUENCE OF COFFEE WITH MILK AND TEA WITH MILK ON THE BIOAVAILABILITY OF TETRACYCLINE, Biopharmaceutics & drug disposition, 18(5), 1997, pp. 459-463
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biopharmaceutics & drug disposition → ACNP
ISSN journal
01422782
Volume
18
Issue
5
Year of publication
1997
Pages
459 - 463
Database
ISI
SICI code
0142-2782(1997)18:5<459:TIOCWM>2.0.ZU;2-3
Abstract
The effect of milk added to coffee or black tea on the bioavailability of tetracycline was evaluated in 12 healthy volunteers according to a crossover design. Results showed that even a small volume of milk con taining extremely small amounts of calcium severely impair the absorpt ion of the drug, so that the presence of this metal ion should be care fully controlled in order to avoid decreasing the available tetracycli ne. (C) 1997 by John Wiley & Sons, Ltd.