Studies on arylfuran derivatives - Part XI. Synthesis, characterisation and biological studies on some Mannich bases carrying 2,4-dichlorophenylfurfural moiety

A series of 3-substituted-4-[5-(2,4-dichlorophenyl)-2-furfurylidine]amino-5 -mercapto-1,2,4-triazoles (3) are synthesised. Aminomethylation of 3 with f ormaldehyde and a primary/secondary amine furnished Mannich bases 4 and 5. Both Schiff bases 3 and Mannich bases 4 and 5 are characterised on the basi s of IR, H-1 NMR, mass spectral data and elemental analysis. All the newly synthesised compounds are tested for their antibacterial activities. Some o f the selected compounds are also tested for their fungicidal and herbicida l properties. (C) 2000 Elsevier Science S.A. All rights reserved.