Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

Background-The glucagon-like peptides (GLP) 1 and 2 are secreted postprandi ally from L cells located mainly in the ileum. Both hormones prolong intest inal transit and GLP-2 is intestinotrophic in rodents. Patients with a jeju nostomy have poor adaptation, rapid gastric and intestinal transit, and imp aired postprandial GLP-2 secretion. Ileum resected short bowel patients wit h a preserved colon snow evidence of functional adaptation and have normal gastric emptying. Aim-To investigate if GLP-1 and GLP-2 contribute to the positive effects of a preserved colon in short bowel patients by measuring circulating levels of GLP-1 and GLP-2 in seven ileum resected short bowel patients with a pres erved colon and seven age and sex matched controls. Methods-GLP-1 and GLP-2 immunoreactivity was measured by specific radioimmu noassays in plasma collected at fasting and at regular intervals 180 minute s after a test meal. Results-Median (25-75%) fasting GLP-2 values were 72 (69-105) pmol/l versus 23 (19-27) pmol/l (p=0.001) and meal stimulated area under the curve was 2 1 078 (14 811-26 610) minxpmol/l versus 11 150 (7151-12 801) minxpmol/l(p=0 .01) in short bowel patients with a preserved colon compared with control s ubjects. Fasting GLP-1 values were 10 (6-12) pmol/l versus 5 (3-5) pmol/l ( p=0.01) and meal stimulated area under the curve was 3418 (2966-6850) minxp mol/l versus 2478 (1929-3199) minxpmol/l (p=0.04), respectively. Conclusion-Ileum resected short bowel patients with a preserved colon had e levated fasting plasma concentrations of GLP-1 and GLP-2 and significantly larger meal stimulated areas under the curve compared with age and sex matc hed controls. Elevated GLP-1 and GLP-2 concentrations may contribute to the positive effects of a preserved colon on intestinal motility and functiona l adaptation in ileum resected short bowel patients.