Benign mullerian inclusions in pelvic and paraaortic lymph nodes

Objective. This study was undertaken to determine the incidence and distrib ution of the location of benign mullerian inclusions in pelvic and paraaort ic lymph nodes. Methods. A total of 114 patients operated on for gynecologic malignancy bet ween 1995 and 1998 underwent surgery including systematic pelvic (n = 114) or pelvic and paraaortic (n = 70) lymphadenectomy. The lymph node material was labeled according to anatomic origin, immediately fixed en bloc, embedd ed in paraffin, and processed as step-serial sections at intervals of 400 m u m. The 5-mu m-thick sections were stained with hematoxylin and eosin. Results. Overall, 26 of 114 patients (23%) had benign mullerian inclusions. Inclusions were most common in the paraarotic (34%), external iliac (12%), and common iliac (9%) regions (P > 0.05). Multiple anatomic sites were inv olved in 14 of 26 patients (54%). Two women had paraaortic inclusions and n egative pelvic nodes. Benign mullerian inclusions were seen in 13 of 51 pat ients (24%) with ovarian carcinoma, 11 of 47 (23%) with cervical carcinoma, 1 of 9 (11%) with endometrial carcinoma, and 1 of 2 with ovarian serous bo rderline tumor, (P > 0.05). Conclusions. Benign mullerian inclusions occur in approximately one-fifth o f patients with gynecologic malignancies in all anatomic regions of pelvic and paraaortic lymph nodes. They must be distinguished from metastatic depo sits. (C) 2000 Academic Press.