Intravesical and intravenous therapy of human bladder cancer by the herpesvector G207

G207, a conditionally replicating herpes vector, efficiently kills human bl adder cancer cells in vitro, To evaluate the therapeutic potential of G207, we have established three in vivo models similar to the clinical situation , In YiYO, G207 was intraneoplastically, intravesically, or intravenously i noculated in nude mice. Intraneoplastic inoculation into subcutaneous tumor caused significant tumor growth inhibition. Intravesical inoculation of G2 07 also caused decreased tumor growth in an orthotopic human bladder cancer model. Furthermore, multiple intravenous inoculation markedly inhibited su bcutaneous tumor growth. These results suggest that intravesical therapy wi th G207 is effective for localized bladder tumor, especially for carcinoma irt situ. (CIS), and intravenous therapy with G207 is promising for invasiv e or metastasized bladder tumor.