Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus

Authors
Entenza, JM Foster, TJ Eidhin, DN Vaudaux, P Francioli, P Moreillon, P
Citation
Jm. Entenza et al., Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus, INFEC IMMUN, 68(9), 2000, pp. 5443-5446
Citations number
24
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
9
Year of publication
2000
Pages
5443 - 5446
Database
ISI
SICI code
0019-9567(200009)68:9<5443:COCFBT>2.0.ZU;2-P
Abstract
Staphylococcus aureus Newman with an insertion mutation in clfB, the gene e ncoding clumping factor B, only marginally decreased infection rate (P > 0. 05) in rats with experimental endocarditis. In contrast, clfB complementati on on a multicopy plasmid significantly increased infectivity (P < 0.05) ov er the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.