Rote of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice

Authors
Adams, LB Job, CK Krahenbuhl, JL
Citation
Lb. Adams et al., Rote of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice, INFEC IMMUN, 68(9), 2000, pp. 5462-5465
Citations number
21
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
9
Year of publication
2000
Pages
5462 - 5465
Database
ISI
SICI code
0019-9567(200009)68:9<5462:ROINOS>2.0.ZU;2-2
Abstract
The manifestation of leprosy in humans is largely determined by host immuni ty to Mycobacterium leprae and is a model for immunoregulation in a human d isease. However, animal models available for exploration of the leprosy spe ctrum are inadequate. This study explored M. leprae infection in mice defic ient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.