Transforming growth factor beta 1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans

Authors
Robinson, P Okhuysen, PC Chappell, CL Lewis, DE Shahab, I Lahoti, S White, AC
Citation
P. Robinson et al., Transforming growth factor beta 1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans, INFEC IMMUN, 68(9), 2000, pp. 5405-5407
Citations number
28
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
9
Year of publication
2000
Pages
5405 - 5407
Database
ISI
SICI code
0019-9567(200009)68:9<5405:TGFB1I>2.0.ZU;2-K
Abstract
Biopsies from volunteers challenged with Cryptosporidium parvum were examin ed for transforming growth factor beta 1 (TGF-beta 1). None of the prechall enge biopsies exhibited TGF-beta. Seven of 12 volunteers with oocyst sheddi ng expressed TGF-beta versus 2 of 13 volunteers without detected oocysts. T he association of TGF-beta expression with oocyst excretion and the timing of symptoms suggests that TGF-beta mediates intestinal healing.