Primary antiphospholipid syndrome presenting with cerebral ischemia, thrombocytopenia, anemia and proteinuria successfully treated with warfarin potassium

A 30-year-old woman with primary antiphospholipid syndrome (PAPS) presented with cerebral ischemia, thrombocytopenia, anemia and proteinuria, Administ ration of warfarin potassium, without concomitant corticosteroid administra tion, significantly improved all of these symptoms along with a decrease in the titers of antiCL-beta(2)-GP-I antibodies and a shortening of prolonged APTT. Therefore, the antiphospholipid antibodies in this patient could hav e been evoked by vitamin-K-dependent coagulation factors or plasma proteins which are assumed to undergo conformational changes exposing cryptic epito pes. This case report provides clues to the mechanisms underlying the produ ction of antiphospholipid antibodies in patients with PAPS.