Prognostic factors in young women with endometrial carcinoma: a report of 20 cases and review of literature

Citation
K. Yamazawa et al., Prognostic factors in young women with endometrial carcinoma: a report of 20 cases and review of literature, INT J GYN C, 10(3), 2000, pp. 212-222
Citations number
47
Categorie Soggetti
Reproductive Medicine
Journal title
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
ISSN journal
1048891X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
212 - 222
Database
ISI
SICI code
1048-891X(200005/06)10:3<212:PFIYWW>2.0.ZU;2-V
Abstract
We, retrospectively reviewed the pathologic features of patients with endom etrial carcinoma (EC) treated in our facility between 1989 and 1998. First, we identified the clincopathologic features of young women with EC a nd compared them with similar patients from the literature. Second, 148 EC patients were divided into two groups: group A (age less than or equal to 4 5 years, n = 20) and B (age>45, n = 128). The mean follow-up periods were 6 5 months and 50 months in groups A and B, respectively. Group A patients ha d better disease-free survival (Kaplan-Meier method, P = 0.0283) compared t o group B patients. The independent variables related to disease-free survi val (Cox regression analysis) were age (P = 0.0001), stage (P = 0.0183), hi stology (P = 0.0011), and lymph node metastasis (P = 0.0007). The distribut ion of stage was significantly different between the two groups (Chi-square test, P = 0.0089). More group A patients (18 of 20; 90%) had early stage d isease. There were no significant differences (Fisher's exact test) between the two groups in histology, grade, cervical involvement, vascular invasio n, tumor size, ovarian malignancy, and lymph node metastasis. However, grou p A patients had a significant higher incidence of disease confined to the inner half of the myometrium than group B patients (P = 0.0004). We statist ically confirmed that young women with EC had better outcome due to a signi ficantly higher proportion of early stage disease and less myometrial invas ion than older patients.