Development of magnetic microbubbles for drug delivery system (DDS)

The purpose of this study is to develop a new ultrasonic contrast agent for the drug delivery system (DDS). Ferromagnetic materials or magnetic carbon s were placed on the surfaces of the surfactant microbubbles developed in O ur laboratory for the above purpose. Multivalent ions such as calcium ions were used to place the ferromagnetic materials or magnetic carbons on the s urfaces of the microbubbles. It was confirmed that the developed magnetic m icrobubbles could be lead by a permanent magnet. Furthermore, the performan ce of the magnetic microbubbles was evaluated by measuring the rime depende nce of the attenuation constant as one of their acoustic properties.