EFFECTS OF INTERLEUKIN-10 ON WATER-INTAKE, LOCOMOTORY ACTIVITY, AND RECTAL TEMPERATURE IN RAT TREATED WITH ENDOTOXIN

Intracerebroventricular (i.c.v.) interleukin-10 (25, 50, and 100 ng/ra t) effects on water intake, exploratory behaviour, and rectal temperat ure were evaluated in rats treated intraperitoneally (i.p.) with lipop olysaccharide (0.32, 0.64, and 0.96 mg/kg). Endotoxin administration i nduced fever and inhibition of thirst in water-deprived rats, and a de crease in lococomotory activity in normohydrated and water-deprived an imals. Our data show that interleukin-10 during lipopolysaccharide adm inistration controlled fever, increases exploratory behaviour, but did not reverse lipopolysaccharide inhibition of thirst. These effects su ggest that fever, depression in locomotory activity but not inhibition of thirst, induced by endotoxin are influenced by interleukin-10 leve ls. (C) 1997 International Society for Immunopharmacology.