PROGRESSIVE RETINITIS-ENCEPHALITIS DUE TO GANCICLOVIR-RESISTANT CYTOMEGALOVIRUS-ASSOCIATED WITH APLASTIC-ANEMIA

A 29-year-old woman with aplastic anemia who complained of visual dist urbances and pain in the right eyeball was diagnosed as having cytomeg alovirus (CMV) retinitis based upon the characteristic retinal changes and isolation of CMV. She received treatment with ganciclovir (GCV), and the retinitis initially responded for several months, However, the patient was found to have CMV lesions in the left eye followed by neu rological symptoms, The CMV isolated just before her death was approxi mately 20 times more resistant to GCV than that isolated previously, s uggesting that the GCV-resistant CMV had developed during the long-ter m treatment with GCV.