Six-year disease-free survival of a patient with metastatic eyelid squamous cell carcinoma and colon adenocarcinoma after repeated postoperative adoptive immunotherapy

A 74-year-old male was affected concurrently with squamous cell carcinoma o f the left eyelid and adenocarcinoma of the colon, both with lymph node met astasis. He underwent exenteration of the left orbit with left modified rad ical neck dissection and subsequently resection of the transverse colon wit h regional lymph node dissection. The patient has been treated by an adopti ve immunotherapy as a sole postoperative modality without receiving any che motherapeutic agents causing immunosuppression. For the adoptive immunother apy, autologous peripheral blood lymphocytes were activated with an immobil ized anti-CD3 antibody and IL-2 for 14 days (the CD3-AT cells). The infusio n with 1.38 x 10(10) CD3-AT cells has been repeated 150 times in total at t he time of writing. Neither recurrence nor additional metastasis has been d etected for 6 years after surgery.