PHASE-II STUDY OF HIGH-DOSE DEXAMETHASONE-BASED ASSOCIATION IN ACUTE AND DELAYED HIGH-DOSE CISPLATIN-INDUCED EMESIS - JCOG-STUDY-9413

Authors
SEKINE I NISHIWAKI Y KAKINUMA R KUBOTA K HOJO F MATSUMOTO T OHMATSU H YOKOZAKI M GOTO K MIYAMOTO T TAKAFUJI J KODAMA T
Citation
I. Sekine et al., PHASE-II STUDY OF HIGH-DOSE DEXAMETHASONE-BASED ASSOCIATION IN ACUTE AND DELAYED HIGH-DOSE CISPLATIN-INDUCED EMESIS - JCOG-STUDY-9413, British Journal of Cancer, 76(1), 1997, pp. 90-92
Citations number
13
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
76
Issue
1
Year of publication
1997
Pages
90 - 92
Database
ISI
SICI code
0007-0920(1997)76:1<90:PSOHDA>2.0.ZU;2-W
Abstract
Thirty-three patients with lung cancer receiving 80 mg m(-2) cisplatin were treated with high-dose dexamethasone (32 mg m(-2) on days 1-3, 1 6 mg m(-2) on day 4 and 8 mg m(-2) on day 5) combined with granisetron on day 1 and metoclopramide on days 2-5. Twenty-eight (85%) patients had no nausea or vomiting on day 1, and 16 (48%) achieved total contro l on days 1-5 with acceptable toxicity. High-dose dexamethasone for ci splatin-induced delayed emesis should be further evaluated in a phase III trial.