The relationship between pulmonary volume-related feedback and inspiratory
(CTI) and expiratory (CTE) phase durations during cough was determined. Cou
gh was produced in anesthetized cats by mechanical stimulation of the intra
thoracic tracheal lumen. During eupnea, the animals were exposed to single-
breath inspiratory and expiratory resistive loads. Cough was associated wit
h large increases in inspiratory volume (VI) and expiratory volume (VE) but
no change in phase durations compared with eupnea. There was no relationsh
ip between VI and CTI during coughing. A linear relationship with a negativ
e slope existed between VI and eupneic inspiratory time during control and
inspiratory resistive loading trials. There was no relationship between VE
and CTE during all coughs. However, when the first cough in a series or a s
ingle cough was analyzed, the VE/CTE relationship had a positive slope. A l
inear relationship with a negative slope existed between VE and eupneic exp
iratory time during control and expiratory resistive loading trials. These
results support separate ventilatory pattern regulation during cough that d
oes not include modulation of phase durations by pulmonary volume-related f
eedback.