Capillary electrophoresis in the pharmaceutical industry: applications in discovery and chemical development

Over the last 10 to 15 years capillary electrophoresis (CE) has become an e xtensively used separation technique in the pharmaceutical industry. The at traction of the various modes of operation of CE to analysts is their compl ementarity to other more established methodology, in particular high-perfor mance liquid chromatography. CE methods have been developed not only for th e resolution of drug substances that vary widely in their structure, size a nd stereochemistry, but also for the determination of the physico-chemical constants of analytes, such as pK(a) and isoelectric point (pI) values, bin ding and complexation constants, and octanol-water partition coefficients. (C) 2000 Elsevier Science B.V. All rights reserved.