Y. Yamaguchi et al., EFFECTS OF GINSENOSIDES ON MAZE PERFORMANCE AND BRAIN CHOLINE-ACETYLTRANSFERASE ACTIVITY IN SCOPOLAMINE-TREATED YOUNG-RATS AND AGED RATS, European journal of pharmacology, 329(1), 1997, pp. 37-41
In young adult rats with scopolamine-induced cognitive impairment, cho
line acetyltransferase activity was increased in the medial septum, bu
t not in the diagonal band, caudate and hippocampus, 30 min after the
injection of ginsenosides Rg1 or Re. Rb1 and Rd had no effect on choli
ne acetyltransferase activity. Aged rats showed a smaller number of in
itial correct responses in the radial-arm maze and a lower choline ace
tyltransferase activity in the medial septum, diagonal band, caudate a
nd hippocampus than did young adult rats. Repeated i.p, injections of
Rg1 increased the number of initial correct responses and the activity
of choline acetyltransferase in the medial septum, but not in the dia
gonal band, caudate and hippocampus, in aged rats. These results sugge
st that Rg1 and Re may contribute the ameliorative effects through an
increase of choline acetyltransferase activity in the medial septum. (
C) 1997 Elsevier Science B.V.