PATHOGENESIS OF RHEUMATOID-ARTHRITIS

Background: Despite ongoing intensive research using sophisticated new molecular tools and methods, the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA) is still not completely understood. Hypothesis: In this paper the two favorite hypotheses of the pathogene sis of rheumatoid arthritis currently discussed are introduced and com pared. Hypothesis 1 is focussing on the central rule of the T cells an d T cell dependent phenomena in the pathogenetic scenario of RA. In co ntrast, hypothesis 2 stresses the role of altered synovial fibroblasts and their specific features critical for the destruction of inflamed joints. Both hypotheses are thoroughly discussed and suggestions for f urther research activities are made. Conclusion: Insights in the patho genesis of RA provide options to develop new therapeutic strategies ai med at the inhibition of pathogenetic relevant processes.