Independent origin of IFN-alpha and IFN-beta in birds and mammals

Authors
Hughes, AL Roberts, RM
Citation
Al. Hughes et Rm. Roberts, Independent origin of IFN-alpha and IFN-beta in birds and mammals, J INTERF CY, 20(8), 2000, pp. 737-739
Citations number
26
Categorie Soggetti
Immunology
Journal title
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
ISSN journal
10799907 → ACNP
Volume
20
Issue
8
Year of publication
2000
Pages
737 - 739
Database
ISI
SICI code
1079-9907(200008)20:8<737:IOOIAI>2.0.ZU;2-P
Abstract
Phylogenetic analysis of type I interferon (IFN) from birds and mammals str ongly supported the hypothesis that the gene duplication giving rise to the alpha and beta families of mammalian IFN occurred after the divergence of birds from mammals, whereas the bird IFN that have been designated alpha an d beta duplicated independently in the avian lineage. Therefore, IFN design ated alpha and beta in birds are not orthologous to those similarly designa ted in mammals.