Diagnosis of central precocious puberty: Endocrine assessment

The new methods which are currently available have provided substantial hel p in performing the differential diagnosis of CPP, especially in detecting very early modifications of gonadotropin secretion. Nocturnal sampling is n ot a practical tool and generates discomfort for patients, and daytime samp les do not yet have sufficient sensitivity; thus, determination of LH level s after GnRH stimulation is the most important test. We emphasize that the use of the GnRH agonist test improves the discrimination of the endocrine i nvestigation, making it easier to differentiate CPP from other conditions, such necessary, but its use in isolation is not as thelarche, Determination of sex steroids is recommended.