Near final height after GnRH agonist treatment in central precocious puberty

The impact of treatment of central precocious puberty (CPP) with gonadotrop in-releasing hormone agonists (GnRHa) on final height remains controversial . We analyzed the long term results of 23 girls with CPP treated with tript orelin or leuprolide. Their "near final height" (NFH) assessed at a bone ag e of at least 14 years and expressed as SDS, was compared either with predi cted height before treatment (PAH) or with parental height (TH), We also co mpared NFH of 12 girls treated before 8 years of age (7.0 +/- 0.5 yr) with NFH of 11 girls treated after 8 years old (8.5 +/- 0.3 yr), The NFH of the 23 girls (-0.9 +/- 1.0 SDS) was not different either from PAH (-0.85 +/- 1. 5 SDS) or from TH (-0.5 +/- 0.6 SDS), Earlier treated girls reached a NFH ( -0.97 +/- 1.0 SDS) not different from later treated girls (-0.91 +/- 1.0 SD S; p = ns) and both groups reached parental height (NFH - TH = -0.44 +/- 1 and -0.09 +/- 0.83 SDS, respectively). In conclusion, our patients, treated either earlier or later, reached a near final height comparable to predict ed height and familial target; however, these results might still improve f urther because the girls have not yet reached their final adult height.