Introduction: Body composition changes with age and sex differences become
significant only after puberty. Boys and girls before the age of 8 yr do no
t differ in fat, lean or bone mineral mass. Hormonal influences during pube
rtal development determine the physiological adult male and female body com
position phenotype,
Aim: The aim of our study was to evaluate body composition changes due to c
entral precocious puberty (PP) and the specific effects of therapy on these
modifications.
Subjects and methods: Sixteen patients (14 girls, 2 boys) were included in
the study, They were diagnosed as affected by idiopathic PP according to st
andard hormonal and clinical criteria; anatomic alterations of hypothalamus
-hypophysis region were excluded by MRI, Mean age at diagnosis was 5.9 +/-
1.9 yr, All patients received GnRH analog (Leuprolide or Triptorelin) treat
ment subcutaneously every 4 weeks for at least 1 yr, Mean period of treatme
nt was 3.4 +/- 1.9 yr, Standard anthropometry and body composition analysis
were performed at baseline and every 6-12 months. A group of healthy subje
cts with normal timing of puberty was matched (for age or for pubertal stag
e) sewed as the control group (CA or CP, respectively).
Results: Patients with PP showed at baseline a significant increase of BMI
and relative body weight; lean and fat compartments were also increased but
not significantly, During treatment, the PP group showed increased fat mas
s compared to CA (p<0.05), while no difference was found between PP and CP,
Lean mass was similar to CA but lower than in CP (p<0.05), During treatmen
t a significant increase in lean mass (both as total as well as limb mass)
was observed. After stopping treatment there was no difference between PP a
nd CP, except for lower lean mass (p<0.04),
Conclusion: When puberty occurs precociously, lean and fat mass are not sig
nificantly different from age-matched control subjects. Data collected duri
ng treatment confirm a shortening of prepubertal lean mass development and
the block of further lean mass development due to puberty itself, while fat
mass accumulation continues. The net result of these modifications determi
nes a typical body composition pattern in PP patients, after the end of the
rapy: lean mass is reduced by a shortening of the prepubertal growing perio
d and by the "menopausal effect" of treatment itself, Fat mass is increased
as a consequence of therapy and could lead to future obesity.