KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn

Authors
Ogihara, T Hirano, K Morinobu, T Ogawa, S Hiroi, M Ban, R Ogihara, H Tamai, H
Citation
T. Ogihara et al., KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn, J PEDIAT, 137(2), 2000, pp. 280-282
Citations number
12
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
JOURNAL OF PEDIATRICS
ISSN journal
00223476 → ACNP
Volume
137
Issue
2
Year of publication
2000
Pages
280 - 282
Database
ISI
SICI code
0022-3476(200008)137:2<280:KAMGAA>2.0.ZU;2-M
Abstract
KL-6 is a mucinous glycoprotein that is preferentially expressed by alveola r type 2 cells. Plasma KL-6 was higher in infants with chronic lung disease (n = 12) than in infants without chronic lung disease (n = 14) on day 0-1, 10, and 30 (P = .04). KL-6 correlated with the alveolar-arterial oxygen te nsion difference on day 10 and day 30. Plasma KL-6 may be useful as an earl y marker of chronic lung disease and an indicator of severity.