New spectrophotometric method for the determination of flutamide in pharmaceutical preparations

A sensitive and simple spectrophotometric method for the determinations of reduction product of flutamide (FLA) is described. The method is based on t he interaction of diazotized flutamide reduction product with N-(1-naphthyl ) ethylenediamine dihydrochloride (NEDA) in neutral or resorcinol (RSL) in alkaline medium. Absorbance of the resulting chromophores is measured at 52 5 or 480 nm, respectively, and is stable for at least 7 days. The two coupl ing reagents are applied successfully for the determination of FLA in table ts. The common excipients used as additives in pharmaceutical preparations do not interfere with the determination. Results from the analysis of pure FLA and its commercial tablets by the proposed methods agree well with the reported method. (C) 2000 Elsevier Science B.V. All rights reserved.