Effects of zinc deficiency during the growing period on behavior of trace elements in mouse

The behavior of Zn and other trace elements in mice fed with Zn-deficient d iet during the growing period (Zn-def. mice) was investigated. A correlatio n between Zn concentration and Co concentration was found in the liver of Z n-def mice. Two types of correlation between Zn and Mn concentrations were also recognised for the same livers. These facts suggest that Zn and Co, an d also Mn are antagonistic, and that Co- and Mn-substitution for Zn-protein s and other Zn-bound compounds may occur, and/or the substituted compounds may be synthesized in the liver of Zn-def. mice.