Synthesis of 5 '-deoxy-5 '-[F-18]fluoro-adenosine by radiofluorination of 5 '-deoxy-5 '-haloadenosine derivatives

Authors
Lehel, S Horvath, G Boros, I Mikecz, P Marian, T Tron, L
Citation
S. Lehel et al., Synthesis of 5 '-deoxy-5 '-[F-18]fluoro-adenosine by radiofluorination of 5 '-deoxy-5 '-haloadenosine derivatives, J RAD NUCL, 245(2), 2000, pp. 399-401
Citations number
10
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
ISSN journal
02365731 → ACNP
Volume
245
Issue
2
Year of publication
2000
Pages
399 - 401
Database
ISI
SICI code
0236-5731(200008)245:2<399:SO5''B>2.0.ZU;2-S
Abstract
5'-Deoxy-5`-[F-18]fluoro-adenosine was synthesised by nucleophilic radioflu orination reactions of 5'-deoxy-5'-haloadenosines. The homogeneous isotope exchange in 5'-deoxy-5'-fluoro-adenosine was also investigated. The convers ion of these reactions was found to be rather low and depends on the streng th of the halogen-carbon bond: 0.248% for chloride-, 0.488% for bromide- an d 1.070% for iodide-derivative; there was no reaction observed in the case of fluoro-compound.