Preparation of Y-90 by the Sr-90-Y-90 generator for medical purpose

Authors
Malja, S Schomacker, K Malja, E
Citation
S. Malja et al., Preparation of Y-90 by the Sr-90-Y-90 generator for medical purpose, J RAD NUCL, 245(2), 2000, pp. 403-406
Citations number
9
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
ISSN journal
02365731 → ACNP
Volume
245
Issue
2
Year of publication
2000
Pages
403 - 406
Database
ISI
SICI code
0236-5731(200008)245:2<403:POYBTS>2.0.ZU;2-W
Abstract
The production of Y-90 by Sr-90-Y-90 generator was studied. Sr-90 was adsor bed on a column with Aminex A-5 resin. The daughter radionuclide Y-90 was e luted with 0.7M alpha-hydroxyisoburyrate (alpha-HIB, pH 5.4). Radionuclidic , radiochemical and chemical purities were >98% and yield >85%. After conve rting into chloride form (YCl3)-Y-90-solution (pH:1) was used for preparing injectable yttrium citrate and labeling some other radiopharmaceuticals. F urthermore, a fast ITLC-method for the determination of Sr-90 in Y-90-eluat e was developed.