Solvent effect on protonation equilibria of L-ornithine and L-glutamic acid

An electrometric investigation of protonation equilibria of L-ornithine and L-glutamic acid in aqua-N,N'-dimethylformamide media of varying compositio n (0-60%, v/v) has been made at different concentrations of the amino acid at 303 K anti an ionic strength of 0.16 mol dm(-3). The best fit chemical m odels are arrived at based on firm statistical grounds employing crystallog raphic R factor, chi(2), skewness and kurtosis. The variation in the proton ation constants with the dielectric constant of the medium is attributed to the electrostatic and non-electrostatic forces.