Amides of Piper amalago var. nigrinodum

An endemic Jamaican variety of Piper amalago has afforded six amides. Four are known compounds, and two (1 and 2) are new. Two-dimensional NMR spectro scopy has been used to assign the structures of the new amides and to assig n completely the H-1 and C-13 NMR spectra of the known compounds. All six a mides have been tested for insecticidal activity against Aedes aegyptii lar vae; some activity is observed and related to molecular features. But none of the compounds show activity against Mycobacterium tuberculosis.