A CONCISE SYNTHESIS OF HYDROXYBUFURALOL

Authors
COLLIER P SCHEINMANN F STACHULSKI AV
Citation
P. Collier et al., A CONCISE SYNTHESIS OF HYDROXYBUFURALOL, Journal of chemical research. Synopses, (8), 1994, pp. 312-313
Citations number
12
Categorie Soggetti
Chemistry
Journal title
Journal of chemical research. Synopses → ACNP
ISSN journal
03082342
Issue
8
Year of publication
1994
Pages
312 - 313
Database
ISI
SICI code
0308-2342(1994):8<312:ACSOH>2.0.ZU;2-4
Abstract
The known ketoaldehyde 5, obtained in four steps from o-hydroxyacetoph enone, is converted in three steps into the drug metabolite hydroxybuf uralol 2 (diastereoisomers); previously 2 had been obtained in a total of thirteen steps from 4-bromophenol via bufuralol 1 itself.