Appropriateness and necessity research of various procedures in medicine ma
y be the most complex field of innovation in healthcare and technology asse
ssment. Nevertheless, the appropriateness of the indication of any medical
intervention is probably more important than the outcome since even ideal q
uality components of structures, processes and outcomes become irrelevant w
ithout a proper indication. The first part of our appropriateness initiativ
e in interventional cardiology and gynecology was to formulate guidelines.
To define the appropriateness for coronary angiography, coronary revascular
ization and hysterectomy, literature-based consensus methods were used. The
second part was to disseminate the guidelines in a user-friendly manner vi
a the Internet. Therefore, we relied on a system-driven query facility for
propositional (experts) rules. The next part of the appropriateness initiat
ive may be a user-friendly Internet-based data collection system to validat
e the national accepted guidelines, Most important may be that only data th
at is needed can be collected using a refined data base technology. The des
cribed Second Opinion System can be found under: http://sos.inf.ethz.ch. Re
search on indications with data on clinical outcome may open new opportunit
ies to validate indication guidelines using Internet/database technology fo
r data analysis and browsing of decision graphs concerning clinical decisio
n-making. This new technology facilitates the evaluation of appropriateness
and necessity criteria in combination with clinical outcomes.