This review discusses the possible causes for the lack of an effective anti
herpes vaccine. Future prospects of vaccines based on the current knowledge
of immune responses to herpes viruses are discussed. It is argued that vac
cines capable of expanding CD8 T-cell memory responses should be the focus
of future anti-herpes simplex virus research. (C) 2000 Editions scientifiqu
es et medicales Elsevier SAS.