Concentration dependence of the effect of Bacillus intermedius ribonuclease on the yeast Saccharomyces cerevisiae

Bacillus intermedius RNase added at a low concentration (0.001 mu g/ml) sti mulated yeast growth, while a high RNase concentration (1500 mu g/ml) was i nhibitory to yeast growth. The inhibitory effect of RNase was transient and correlated with the increase in the trehalose pool of yeast cells. The num ber of unbudded cells in the yeast population tended to decrease under the action of low concentrations of bacillar RNase and to increase under the ac tion of high concentrations of this enzyme.