Mp. Bigatti et al., Chromosomal aberrations, sister chromatid exchanges and high frequency cells in young patients with neurofibromatosis 1 (NF1), NEOPLASMA, 47(4), 2000, pp. 234-238
Chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and high f
requency cells (HFCs) have been assessed in peripheral blood lymphocytes of
10 neurofibromatosis (NF1) patients and 10 healthy controls.
In both groups, the spontaneous rates and the induced (bleomycin for CA and
MMC for SCE) frequencies were analyzed. No differences between cells from
NF1 patients and controls were observed with respect to spontaneous or bleo
mycin induced CA. Spontaneous or MMC induced SCE frequencies were also simi
lar in NF1 patients and controls. HFCs, on the contrary, were statistically
lower in NF1 patients.