Carboplatin and cyclophosphamide in the treatment of metastatic seminoma

Cisplatin-based chemotherapy is highly effective in advanced seminoma, but at the cost of a considerable toxicity. The response rate of carboplatin is comparable with cisplatin combinations but the relapse rate is higher. Our study assesses the efficacy and the toxicity of the combination of carbopl atin and cyclophosphamide in patients with advanced seminoma. Nineteen consecutive patients received 6 cycles of intravenous cyclophospha mide 750 mg/m(2) and carboplatin 350 mg/m(2), repeated every 21 days. The o verall objective response rate was 100%, 11 patients (58%) achieved a compl ete response and 8 patients (42%) showed a partial response. At median foll ow up of 4.2 years 3 patients (15%) relapsed. The 2-year disease-free survi val and the overall survival are 72 and 94%, respectively. This outpatient treatment was well tolerated and the toxicity was mild. One patient had gra nulocytopenic fever and one patient had grade 3 cystitis. The combination t herapy with carboplatin and cyclophosphamide is an effective and tolerable regimen in advanced seminoma.