The authors describe five patients with typical clinical and MRI features o
f CSF leak and large enhancing pituitaries. The source of CSF leak was iden
tified and surgically repaired in three patients. This was followed by disa
ppearance of clinical symptoms and resolution of MRI abnormalities, includi
ng the pituitary enlargement. Enhancing enlargement of pituitary is another
head MRI abnormality in CSF leaks, likely reflecting a secondary pituitary
hyperemia.