Anti-GM1 antibody facilitates leakage in an in vitro blood-nerve barrier model

Authors
Kanda, T Iwasaki, T Yamawaki, M Tai, T Mizusawa, H
Citation
T. Kanda et al., Anti-GM1 antibody facilitates leakage in an in vitro blood-nerve barrier model, NEUROLOGY, 55(4), 2000, pp. 585-587
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
55
Issue
4
Year of publication
2000
Pages
585 - 587
Database
ISI
SICI code
0028-3878(20000822)55:4<585:AAFLIA>2.0.ZU;2-V
Abstract
Using an in vitro blood-nerve barrier (BNB) model, the authors tested the e ffect of various monoclonal antiganglioside antibodies on BNB function. Onl y anti-GM1 antibody significantly facilitated BNB leakage in a concentratio n-dependent, complement-independent manner. This study provided evidence th at anti-GM1 antibody, frequently detected in sera from patients with inflam matory neuropathies, may participate BNB dysfunction and contribute to deve lopment of neuropathy.