Polymorphism at codon 129 of the prion protein gene is not associated withsporadic AD

Authors
Combarros, O Sanchez-Guerra, M Llorca, J Alvarez-Arcaya, A Berciano, J Pena, N Fernandez-Viadero, C
Citation
O. Combarros et al., Polymorphism at codon 129 of the prion protein gene is not associated withsporadic AD, NEUROLOGY, 55(4), 2000, pp. 593-595
Citations number
8
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
55
Issue
4
Year of publication
2000
Pages
593 - 595
Database
ISI
SICI code
0028-3878(20000822)55:4<593:PAC1OT>2.0.ZU;2-F
Abstract
An association between cognitive performance in elderly people and variabil ity in the codon 129 of the prion protein gene (PRNP) has been recently des cribed. The authors analyzed this polymorphism in 278 sporadic AD patients and 268 cognitively normal control subjects. Analyses stratifying by APOE g enotype, age, and gender failed to reveal any association between homozygos ity for the 129 PRNP methionine or valine alleles and AD.