NEW METHOD OF PREPARING HIGH-POROSITY RAPIDLY SALIVA SOLUBLE COMPRESSED TABLETS USING MANNITOL WITH CAMPHOR, A SUBLIMING MATERIAL

Compressed tablets of a water-soluble material, prepared using mannito l, did not rapidly dissolve in water since it is difficult for water t o penetrate into the tablets due to their low porosity. To increase th e porosity of the tablets which are prepared by direct compression usi ng mannitol, we developed a novel method whereby camphor, a subliming material, is removed by sublimation from compressed tablets prepared u sing a mixture of mannitol and camphor. A high porosity was achieved d ue to the formation of many pores where camphor particles previously e xisted in the compressed mannitol tablets prior to sublimation of the camphor. These compressed tablets which have high porosity (approximat ely 30%) rapidly dissolved within 15 s in saliva in the mouth. We deve loped a direct compression method for the preparation, using mannitol and camphor, of a meclizine (antidinic agent) tablet with high porosit y which dissolves rapidly in saliva. (C) 1997 Elsevier Science B.V.