K. Koizumi et al., NEW METHOD OF PREPARING HIGH-POROSITY RAPIDLY SALIVA SOLUBLE COMPRESSED TABLETS USING MANNITOL WITH CAMPHOR, A SUBLIMING MATERIAL, International journal of pharmaceutics, 152(1), 1997, pp. 127-131
Compressed tablets of a water-soluble material, prepared using mannito
l, did not rapidly dissolve in water since it is difficult for water t
o penetrate into the tablets due to their low porosity. To increase th
e porosity of the tablets which are prepared by direct compression usi
ng mannitol, we developed a novel method whereby camphor, a subliming
material, is removed by sublimation from compressed tablets prepared u
sing a mixture of mannitol and camphor. A high porosity was achieved d
ue to the formation of many pores where camphor particles previously e
xisted in the compressed mannitol tablets prior to sublimation of the
camphor. These compressed tablets which have high porosity (approximat
ely 30%) rapidly dissolved within 15 s in saliva in the mouth. We deve
loped a direct compression method for the preparation, using mannitol
and camphor, of a meclizine (antidinic agent) tablet with high porosit
y which dissolves rapidly in saliva. (C) 1997 Elsevier Science B.V.